These Saints were from the city of Edessa in Mesopotamia and flourished during the reign of Justin the Younger (565-578). After a pilgrimage to Jerusalem they were moved with a desire to forsake the world; they were tonsured monks by the Abbot Nicon, and soon after left the monastery to struggle together in the wilderness near the Dead Sea. When they had passed a little more than thirty years together in silence and prayer, Symeon, having reached the heights of dispassion, departed for Emesa in Syria, where he passed the rest of his life playing the fool, saving many souls from sin while hiding his sanctity with seemingly senseless behavior. He reposed in 570; by the providence of God, John, who had remained in the wilderness, departed soon after.

Saint Mary was from Magdala in Galilee on the Sea of Tiberias, and for this was named Magdalene. When the Lord Jesus cast out seven demons from her, from which she had been suffering, she became His faithful and inseparable disciple, following Him and ministering unto Him even to the time of His crucifixion and burial. Then, returning to Jerusalem together with the rest of the Myrrh-bearers, she prepared the fragrant spices for anointing the body of the Lord. And on the Lord's day they came very early to the tomb, even before the Angels appeared declaring the Resurrection of the Lord. When Mary Magdalene saw the stone taken away from the tomb, she ran and proclaimed it to Peter and John. And returning immediately to the tomb and weeping outside, she was deemed worthy to be the first of the Myrrh-bearers to behold the Lord arisen from the dead, and when she fell at His feet, she heard Him say, "Touch Me not." After the Lord's Ascension, nothing certain is known concerning her. Some accounts say that she went to Rome and later returned to Jerusalem, and from there proceeded to Ephesus, where she ended her life, preaching Christ. Although it is sometimes said that Saint Mary Magdalene was the "sinful woman" of the Gospel, this is nowhere stated in the tradition of the Church, in the sacred hymnology, or in the Holy Gospels themselves, which say only that our Lord cast seven demons out of her, not that she was a fallen woman. "Madeleine" is a form of Magdalene.