Saint Gregory was born in Neocaesarea of Pontus to parents who were not Christians. He studied in Athens, in Alexandria, in Beirut, and finally for five years in Caesarea of Palestine under Origen, by whom he was also instructed in the Faith of Christ. Then, in the year 240, he became bishop of his own city, wherein he found only seventeen Christians. By the time the Saint reposed about the year 265, there were only seventeen unbelievers left there. Virtually the whole duration of his episcopacy was a time of continual, marvellous wonders worked by him. Because of this, he received the surname "Wonderworker"; even the enemies of the truth called him a second Moses (see Saint Basil the Great's On the Holy Spirit, ch. 29).

The Divine Scriptures do not tell us with any certainty when the Prophet Obadiah lived nor what was his homeland. Thus, some say that he is that Obadiah who was Ahab's steward, who, because of Jezebel's wrath, hid one hundred prophets in a cave and fed them with bread and water (III Kings 18:4), and that he later became a disciple of Elias the Prophet about 903 B.C. But others surmise from the words of the same prophetical book that he is somewhat later than Joel (celebrated on Oct. 19). He is also called Obdiu, or Abdiu, or Obadiah; his name means "servant of God." His book of prophecy, which consists of only one chapter, is ranked fourth among the minor Prophets.

Saint Amphilochius, who was born in Cappadocia, shone forth in asceticism and divine knowledge even from his youth. He was consecrated Bishop of Iconium in 341, he struggled courageously against the blasphemies of Eunomius, Macedonius the enemy of the Holy Spirit, and the followers of Arius. He was present at the Second Ecumenical Council of the 150 Fathers, which took place in Constantinople, convoked during the reign of Theodosius the Great in the year 381. In 383 Amphilochius wished to persuade the Emperor Theodosius to forbid the Arians from gathering in Constantinople and to commit the churches to the Orthodox, but the Emperor was reluctant to do such a thing. The next time that Amphilochius entered the palace, he addressed Theodosius with proper honour, but slighted his young son Arcadius in his presence. Theodosius was indignant, and said the dishonour shown to his son was equally an insult to himself. To this Saint Amphilochius answered that as he would not suffer an insult to his son, so he ought to believe that God is wroth with those who blaspheme His Only-begotten. Saint Theodosius understood and admired Amphilochius' ingenious device, and he issued the desired edict in September of the same year. Saint Amphilochius, having reached deep old age, reposed in peace about the year 395. Saint Basil the Great wrote many letters to Saint Amphilochius, his friend and Fellow champion of the Faith, and at his request wrote his treatise On the Holy Spirit, which besides demonstrating the divinity of the Holy Spirit and His equality with the Father and the Son, defends the Church's unwritten ancient traditions, such as making the sign of the Cross, turning towards the East in prayer, no kneeling on Sunday, and so forth.