This Apostle was an Antiochean, a physician by trade, and a disciple and companion of Paul. He wrote his Gospel in Greek after Matthew and Mark, after which he wrote the Acts of the Apostles, and dedicated both works to Theophilus, who, according to some, was Governor of Achaia. He lived some eighty-six years and died in Achaia, perhaps in Patras, the capital of this district. His emblem is the calf, the third symbolical beast mentioned by Ezekiel (1:10), which is a symbol of Christ's sacrificial and priestly office, as Saint Irenaeus says.

Saint John of Rilas founded the renowned monastery of that name in Bulgaria in the tenth century. Over the centuries, great and wondrous healings have flowed from his holy relics.

Saint Artemius lived during the years of Saint Constantine the Great, and was appointed by him to be Governor of Alexandria; later, he was honoured with the rank of patrician. During the reign of Julian the Apostate, in the year 361, Artemius appeared before the Emperor and censured him for his apostasy. For this, he endured many torments and was finally beheaded.

Saint Abercius, Bishop of Hierapolis in Phrygia in the times of Marcus Aurelius, was adorned with the grace of wonderworking and with apostolic zeal. During a festival in honour of Apollo, the chief deity of Hierapolis, the holy bishop was instructed in a revelation to destroy the idols. He went to the temple by night and overturned the statues of Apollo and the others. When this was discovered, the Saint boldly cried out that the gods, becoming drunk from the wine of the libations offered them, had struck one against another in their confusion. A multitude of furious pagans came to avenge the insult to their gods, but when the Saint cast the demons out of three afflicted young men, fear fell upon the idolaters and they with the whole city became Christian. After many labours, and afflictions, Saint Abercius reposed in peace about the year 167 (or, according to some, 186).

According to some, this Saint was a son of Joseph the Betrothed, born of the wife that the latter had before he was betrothed to the Ever-virgin. Hence he was the brother of the Lord, Who was also thought to be the son of Joseph (Matt. 13: 55). But some say that he was a nephew of Joseph, and the son of his brother Cleopas, who was also called Alphaeus and Mary his wife, who was the first cousin of the Theotokos. But even according to this genealogy, he was still called, according to the idiom of the Scriptures, the Lord's brother because of their kinship.

This Iakovos is called the Less (Mark 15:40) by the Evangelists to distinguish him from Iakovos, the son of Zebedee, who was called the Great. He became the first Bishop of Jerusalem, elevated to this episcopal rank by the Apostles, according to Eusebius (Eccl. Hist., Book II: 23), and was called Obliah, that is, the Just, because of his great holiness and righteousness. Having ascended the crest of the Temple on the day of the Passover at the prompting of all, he bore testimony from there concerning his belief in Jesus, and he proclaimed with a great voice that Jesus sits at the right hand of the great power of God and shall come again upon the clouds of heaven. On hearing this testimony, many of those present cried, "Hosanna to the Son of David." But the Scribes and Pharisees cried, "So, even the just one hath been led astray," and at the command of Ananias the high priest, the Apostle was cast down headlong from thence, then was stoned, and while he prayed for his slayers, his head was crushed by the wooden club wielded by a certain scribe. The first of the Catholic (General) Epistles written to the Jews in the Diaspora who believed in Christ was written by this Iakovos.

These Martyrs contested for piety's sake in the year 524 in Najran, a city of Arabia Felix (present-day Yemen). When Dhu Nuwas, ruler of the Himyarite tribe in south Arabia, and a Judaizer, took power, he sought to blot out Christianity, especially at Najran, a Christian city. Against the counsels of Arethas, chief man of Najran, the city surrendered to Dhu Nuwas, who immediately broke the word he had given and sought to compel the city to renounce Christ. Led by Saint Arethas, hundreds of martyrs, including women, children, and babes, valiantly withstood his threats, and were beheaded and burned. After the men had been slain, all the free-born Christian women of Najran were brought before the tyrant and commanded to abjure Christ or die; yet they rebuked the persecutor with such boldness that he said even the men had not insulted him so contemptuously. So great was their faith that not one woman was found to deny Christ in all Najran, although some of them suffered torments more bitter than most of the men. In alliance with Byzantium, the Ethiopian King Elesbaan liberated Najran from Dhu Nuwas soon after and raised up churches in honour of the Martyrs. Najran became a place of pilgrimage until the rise of Islam a century later. At the end of his life King Elesbaan, who was also called Caleb, retired into solitude as a hermit; he sent his crown to Jerusalem as an offering to the Church of the Holy Sepulchre. He also is commemorated on this day as a saint. Saint Arethas' name in Arabic, Harith, means "plowman, tiller," much the same as "George" does in Greek.