Saint Macarius the Great was from the Thebaid of Egypt, a disciple, as some say, of Saint Anthony the Great. He was born about 331 and struggled in asceticism in the desert at Scete. Although young, he was called "the child elder" because of his great wisdom and austere manner of life. He was ordained presbyter and reposed in 391, at the age of sixty. There are fifty homilies ascribed to him.

It is said of Saint Macarius that he became as a God upon earth, for even as God protects the whole world, so did he cover the faults he saw as if he did not see them. Once he came back to his cell to find a thief taking his things and loading them on a camel. Macarius' non-possessiveness was so great that he helped the thief load the camel. When the camel refused to rise, Macarius returned to his cell and brought a small hoe, said that the camel wanted the hoe also, loaded it on, and kicked the camel telling it to get up. The camel obeyed Macarius' command, but soon lay down again, and would not move until everything had been returned to Macarius. His contemporary, Saint Macarius of Alexandria, was so called because he came from Alexandria and was therefore of that Greek-speaking colony; while Saint Macarius the Great is also called "of Egypt," that is, he belonged to the ancient race native to Egypt, the Copts.

Saint Macarius of Alexandria, was so called because he came from Alexandria and was therefore of that Greek-speaking colony; while Saint Macarius the Great is also called "of Egypt," that is, he belonged to the ancient race native to Egypt, the Copts. Whenever Saint Macarius of Alexandria heard of a virtue practiced by any man, he strove to practice it even more fully himself. When he was already old, he visited the community of Saint Pachomius in Tabennisi and, without revealing who he was, asked admittance. Saint Pachomius, on account of Macarius' age, was reluctant to receive him, but after-wards yielded to his entreaties. Shortly thereafter Great Lent began, and Macarius followed such a severe rule of fasting and prayer that many in the brotherhood complained to Pachomius asking if he had brought this old man to put them to shame. Learning Macarius' identity in a revelation, Saint Pachomius thanked him for breaking the pride of his monks and sent him away in peace.