Saint Gregory was born in Neocaesarea of Pontus to parents who were not Christians. He studied in Athens, in Alexandria, in Beirut, and finally for five years in Caesarea of Palestine under Origen, by whom he was also instructed in the Faith of Christ. Then, in the year 240, he became bishop of his own city, wherein he found only seventeen Christians. By the time the Saint reposed about the year 265, there were only seventeen unbelievers left there. Virtually the whole duration of his episcopacy was a time of continual, marvellous wonders worked by him. Because of this, he received the surname "Wonderworker"; even the enemies of the truth called him a second Moses (see Saint Basil the Great's On the Holy Spirit, ch. 29).

Saint Plato contested in martyrdom in 266, when Agrippinus was proconsul. He was from the city of Ancyra in the province of Galatia.

Saint Barlaam, who was from a certain village near Antioch in Syria, was advanced in years and a husbandman by occupation. Because of his confession of Christ, he was brought before the judge, who had him scourged with whips and then scraped with iron claws. Since this could not break his constancy, he was forcibly haled to the idols' temple, and live coals with incense were placed in his right hand. The judge thought that he would cast them down because of the pain, thus seeming to have offered a sacrifice of incense to the idols. But Saint Barlaam stood unmoving until his hand was thoroughly burned by the coals; he fell to the ground, and so gave up his soul into the hands of the Lord. He contested in martyrdom during the reign of Diocletian (284-305). Saint Basil the Great and Saint John Chrysostom both gave homilies in his honour.

Saint Proclus lived during the reign of Saint Theodosius the Younger. A disciple and scribe of Saint John Chrysostom, he was ordained Bishop of Cyzicus about the year 426, but because the people there unlawfully elected another bishop before his arrival, he remained in Constantinople. In 429, Nestorius, who had been Archbishop of Constantinople for about a year, and had already begun his blasphemous teaching that it is wrong to call the holy Virgin "Theotokos," invited Bishop Proclus to give a sermon on one of the feasts of our Lady, which he did, openly defending in Nestorius' presence the name "Theotokos," that is, "Mother of God." Saint Proclus was elevated to the throne of Archbishop of Constantinople in 434. It was he who persuaded Emperor Theodosius the Younger and his holy sister Pulcheria to have the most sacred relics of his godly teacher Saint John Chrysostom brought back from Comana, and triumphantly received them upon their return to the imperial city (see Jan. 27 and Nov. 13). He reposed in peace in 447.

According to the tradition of the Church, the Theotokos was brought to the Temple at three years of age, where she was consecrated to God and spent her days until she was fourteen or fifteen years old; and then, as a mature maiden, by the common counsel of the priests (since her parents had reposed some three years before), she was betrothed to Joseph.

Saint Cecilia was of an illustrious Roman family. On being betrothed to Valerian, she drew him to the Faith of Christ, and he in turn drew his own brother Tiburtius to the same. They contested in martyrdom during the reign of Diocletian, in the year 288.

Saint Amphilochius, who was born in Cappadocia, shone forth in asceticism and divine knowledge even from his youth. He was consecrated Bishop of Iconium in 341, he struggled courageously against the blasphemies of Eunomius, Macedonius the enemy of the Holy Spirit, and the followers of Arius. He was present at the Second Ecumenical Council of the 150 Fathers, which took place in Constantinople, convoked during the reign of Theodosius the Great in the year 381. In 383 Amphilochius wished to persuade the Emperor Theodosius to forbid the Arians from gathering in Constantinople and to commit the churches to the Orthodox, but the Emperor was reluctant to do such a thing. The next time that Amphilochius entered the palace, he addressed Theodosius with proper honour, but slighted his young son Arcadius in his presence. Theodosius was indignant, and said the dishonour shown to his son was equally an insult to himself. To this Saint Amphilochius answered that as he would not suffer an insult to his son, so he ought to believe that God is wroth with those who blaspheme His Only-begotten. Saint Theodosius understood and admired Amphilochius' ingenious device, and he issued the desired edict in September of the same year. Saint Amphilochius, having reached deep old age, reposed in peace about the year 395. Saint Basil the Great wrote many letters to Saint Amphilochius, his friend and Fellow champion of the Faith, and at his request wrote his treatise On the Holy Spirit, which besides demonstrating the divinity of the Holy Spirit and His equality with the Father and the Son, defends the Church's unwritten ancient traditions, such as making the sign of the Cross, turning towards the East in prayer, no kneeling on Sunday, and so forth.